Synthetic polymers used in various transport systems has revealed previously

Synthetic polymers used in various transport systems has revealed previously. Several polymers of PEG such as polyethylene glycol, polyethylene glycol based detergent, others like poloxamers, dentrimers, and thiomers, played a important role in various formulations and has been investigated for the efflux pump inhibitory activity.
Polyethylene glycol and its derivatives PEG 400 (5% w/v) restrict digoxin transport in secretory direction and on other side restriction found regardless by addition of PEG 400 which was concluded decreased P-gp activity at apical side was studied by Johnson et al. PEG 400 have indirect effect in efflux restriction of digoxin which proved the effect of PEG on P-gp activity to illustrate interaction between PEG 200,300,400 using caco-2 cell monolayers was studied by Ashiru-Oredope et al.